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L-Methylfolate (5-MTHF)

Vitamins/Minerals · Evidence: Moderate · Importance: Optional

An active folate form some prefer, particularly those with MTHFR variants.

Educational only — not medical advice. BodEvo summarizes research cautiously and labels estimates as estimates. Talk to a physician or registered dietitian before starting any supplement, diet, or training program.

What the evidence says

A bioactive folate; whether it beats folic acid for most people is debated, but it is a valid folate source.

Typical dose & timing

Dose: Per label; folate RDA is ~400 mcg DFE.

Timing: With meals.

Role in a stack

Active folate alternative to folic acid.

Redundancy check: Redundant with a folate-containing multivitamin for most people.

Cautions & safety

High folate can mask B12 deficiency — assess B12 too. Discuss MTHFR testing/decisions with a clinician.

Coordinate with B12 status. Educational only — not medical advice.

Best for

folate needs · some MTHFR contexts (with clinician input)

Use it in the app: open the Supplement Library and Stack Builder — free, local-first, no account required.