Betaine Anhydrous / TMG

Performance · Evidence: Mixed · Importance: Low

May support power output, hydration/osmolyte balance, and methylation.

What the evidence says

Inconsistent evidence for strength/power output.

Typical dose & timing

Dose: 1.25–2.5 g daily

Timing: Daily or pre-workout.

Role in a stack

Optional performance support.

Redundancy check:

Cautions & safety

May cause GI upset. Not a foundational supplement.

Some evidence but mixed results across studies.

Best for

performance-focused users after basics are covered

Source-verified products

Real products in this category, ordered by review count. Each price and rating comes from the product's own page, recorded 2026-07-29 — follow the link for current values. Links go to the product's source page and never affect this ranking.

• Life Extension, TMG, 500 mg, 60 Liquid Vegetarian Capsules
  Life Extension · $10.13 · 4.8/5 (7105 ratings) · budget tier
• NOW Foods, TMG, 1,000 mg, 100 Tablets
  NOW Foods · $17.14 · 4.8/5 (4997 ratings) · mid tier
• Nutricost, TMG, 750 mg, 120 Capsules
  Nutricost · $10.00 · 4.8/5 (1692 ratings) · budget tier
• Swanson Vitamins, TMG, 500 mg, 90 Capsules
  Swanson Vitamins · $11.09 · 4.8/5 (1671 ratings) · budget tier
• ProHealth Longevity, TMG Pro, 1,000 mg, 120 Tablets
  ProHealth Longevity · $16.57 · 4.6/5 (757 ratings) · mid tier
• Force Factor, TMG Betaine, 180 Vegetable Capsules (500 mg per Capsule)
  Force Factor · $17.99 · 4.8/5 (620 ratings) · premium tier
• Kirkman Labs, TMG , 120 Capsules
  Kirkman Labs · $36.75 · 4.7/5 (608 ratings) · premium tier
• Source Naturals, TMG, 750 mg, 240 Tablets
  Source Naturals · $28.16 · 4.8/5 (564 ratings) · premium tier
• Allergy Research Group, TMG, 100 Vegetarian Capsules (750 mg Per capsule)
  Allergy Research Group · $26.29 · 4.7/5 (279 ratings) · premium tier
• Vitamatic, TMG, 1,000 mg, 120 Tablets
  Vitamatic · $9.99 · 4.6/5 (232 ratings) · budget tier
• Nutricost Betaine Anhydrous (TMG) Powder
  Nutricost · $17.97 · 4.31/5 (124 ratings) · mid tier
• BrainMD, Betaine TMG, 60 Vegan Capsules (500 mg per Capsule)
  BrainMD · $15.50 · 4.9/5 (74 ratings) · mid tier

References

• Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. European Journal of Applied Physiology (2013)
  Evidence is mixed. Some trials show modest improvements in power output and hormonal responses; others show no significant effect. Not a high-priority supplement.